YES Network.com

NEW YORK -- Johnny Vander Meer, you still stand alone as the only pitcher in the history of baseball to toss two consecutive no-hitters.

Johan Santana, who pitched the first no-no in Mets history, worked a perfect first inning Friday night against the Yankees. Alex Rodriguez walked to lead off the second and Robinson Cano followed with the first hit of the game. Cano blasted Santana’s first pitch into the right-field bleachers for a two-run home run that ended the left-hander’s bid to match Vander Meer and snapped his scoreless innings streak at 19.

The home run, Cano’s first off Santana, raised his lifetime average against the Mets lefty to .391.

But he wasn’t finished, not even close.

Cano blasted another two-run bomb in the third, this time to the second deck in right. Solo home runs by Nick Swisher and Andruw Jones followed, which was the first time the Yankees connected on back-to-back-to-back homers since Swisher, Cano and Melky Cabrera did it in the second inning against the Orioles on May 20, 2009.

Cano’s 11 homers rank second behind Curtis Granderson for the team lead. He has eight long balls in his last 19 games after belting only three in his first 38 of the season.

Santana pitched five innings, allowing six runs on seven hits and one walk. He struck out five batters.

The Mets' ace has not fared well at the new Yankee Stadium. In three career starts there, the Yankees are batting .375 (24-64) against Santana with six home runs. He has pitched to a 12.21 ERA.

Follow Jon Lane on Twitter: @JonLaneNYC